Background: Postpartum depression (PPD) is a significant complication that many new mothers face during pregnancy and in the weeks and months following a child's birth. Quantitative data suggest that a mother’s PPD negatively impacts routine well-visits and pediatric care for the new child. However, little is known about what challenges or facilitates their healthcare decision-making. Objective: This qualitative study used interpretative phenomenological analysis (IPA) to explore and understand mothers’ perceptions about healthcare decision-making while having experienced PPD. This study also investigated a mother’s perceptions and experiences of making routine vaccination decisions during the child’s first year of life while having PPD. Method: Using IPA, the researcher used purposive sampling to recruit eight individuals from local clinics and community organizations that met the study’s inclusion criteria. Participants were interviewed about their PPD experiences and healthcare decision-making influences through a semi-structured interview. Transcribed interviews and initial interpretations were shared with participants to clarify information and aid in the analysis process. The researcher followed a heuristic process for analyzing interview data to cultivate a deeper understanding of the study topic. Results: Four super-ordinates themes were discovered. Those themes pertained to mothers’ relationship with their clinician, stress, depression, and anxiety contributors during PPD, impacts of PPD on mothering and baby, support structures for mother and baby. Discussion: The experience of universality connected all themes and identified the need for cohesive approaches from clinical providers of pre- and postnatal care. Group model approaches to postnatal care appear to mitigate or reduce the impact of PPD.