The Occupational Performance Inventory of Sexuality and Intimacy (OPISI) was created to aid occupational therapy practitioners in overcoming barriers that prevent them from assessing and addressing sexuality and intimacy with their clients. The purpose of this study was to validate the OPISI to establish the tool’s legitimacy and instill practitioners with confidence in their ability to accurately assess sexual and intimate occupations. A modified Delphi technique was used to further develop and validate the OPISI which consisted of three iterative rounds with the purpose of gaining consensus between a panel of experts. Each round focused on gathering feedback on items concerning clarity, relevance, importance, and inclusion within the final tool. Through iterative rounds, researchers added, modified, and removed items until all items reached 80% agreement among the expert panel members. The OPISI was created to comprehensively screen, assess, and measure performance related to the complex occupational nature of sexuality and intimacy. With the OPISI validated and published, it is imperative that occupational therapy practitioners assess and address their client’s sexuality and intimacy concerns. The OPISI tools are available for download at http://uindy.opisi.edu.