Refugee mental health has been very under-researched in terms of the impact and implications their experiences have for treatment (Kim & Keovisai, 2016; Trieu & Vang, 2015). Burmese refugees, specifically, are even less present in refugee mental health research despite being one of the largest groups to relocate in the past 20 years, and the largest to relocate to the United States in the past 10 years (Kim, 2018; Kumar, 2020; Ngo-Metzer et al., 2010). Adolescent mental health has also been relatively under-researched despite this being a common age of onset, the chronicity of disorders, and psychosocial impact of mental health disorders when left untreated (Baker et al., 2021; Kendall et al., 1989; Kendall & Peterman, 2015; Strauss et al., 1987). The overall lack of research of refugee and adolescent mental health is reflected in treatment outcome studies. To date, there is no treatment outcome study for adolescent Burmese refugees in a Western country. The effectiveness of cognitive-behavioral treatment for generalized anxiety disorder and major depressive disorder in an adolescent refugee was examined. The patient, an adolescent Burmese refugee, was selected from an integrated primary care clinic in a Midwestern city. The patient received cognitive-behavioral therapy (CBT) for a diagnosis of generalized anxiety and major depressive disorder. Effectiveness of treatment was measured by comparing pre- and post-treatment scores on the Patient Health Questionnaire-9 and Generalized Anxiety Disorder Scale-7. The data was analyzed for statistical and clinical significance using the reliable change index (RCI). The calculated RCI did not suggest a significant change in the patient’s pre- and post-treatment scores. Treatment suggestions based on Chomden’s treatment outcome and future research directions are presented.