Background: Nurses are at high risk for developing work-related musculoskeletal disorders (WMSDs). Ergonomics programs assist in decreasing risk factors associated with WMSDs. This study aimed to develop a multifaceted ergonomics interventions program to increase awareness of ergonomics interventions to reduce overall risk factors of WMSDs and increase occupational therapy referral to address ergonomics issues. Method: A two-part ergonomics program was created and implemented. Part one focused on nurses’ training on the use of the friction reduction slide sheet (FRS). In part two, the researcher developed educational material with a holistic approach. Portions of the Rapid Upper Limb Assessment (RULA) and a pre/post questionnaire were used to determine effectiveness. Result: Thirteen burn nurses participated in the program. The participants increased their awareness of WMSDs and identifying the risk factors. The participants used the FRS training and ergonomics techniques for adapting and modifying the environment to decrease risk. All participants felt the program provided adequate information and applied it to work routines. Conclusion: In conclusion, an occupational therapist-led, multifaceted ergonomics program helps nurses increase awareness of WMSDs, provides a comprehensive method for reducing risk factors in the workplace, and helps increase occupational therapy referrals to address ergonomics issues.