Chronic nursing fatigue is an issue that continues to put patients at risk. Heavier workloads and longer work hours increase nursing fatigue. Critical care (CC) nurses may be more at risk to develop chronic fatigue, which may negatively affect patient outcomes. The purpose of this quantitative study was to 1) discover the prevalence of chronic fatigue within CC nurses in Indiana; 2) explore the relationship between chronic nursing fatigue, workload, and work hours; and 3) explore attitudes toward regulatory work hour policies and if they correlate with chronic fatigue levels. Likert-style surveys were used to explore CC nurse chronic fatigue levels as well as their workloads, work hours, and work hour regulatory policy attitudes. No correlations or significant differences were found between chronic fatigue total scores, workload totals scores, work hours, or policy attitudes. Most surveyed reported moderate to high levels of chronic fatigue (62.5%) and moderate workloads (63.6%). Nurses who were older and those who had practiced longer had higher mean chronic fatigue scores. Almost all surveyed worked 12- hour shifts and at least 72-hours every two weeks. The majority of participants were unsure if work hour restriction policies should be adopted. The results of this study indicate a need for interventions that help alleviate and/or prevent chronic fatigue in CC nurses working in Indiana. Interventions should address chronic fatigue statements that received the highest mean ratings as well as consider nurse age and years of practice. More research must be done to explore nursing work restriction policies and the knowledge and attitudes that CC nurses have about them in order to understand policy feasibility and benefits.